Hi Layla. My mother has hac C Diff twice, each time after taking antibiotics. I got it in February while hospitalized and given prophylactic antibiotics. My doc has told me that now that I've had it, I'll have to take vanco (allergic to flagyl) each time I take AB's. My mom has chronic UTI's, and takes flagyl with AB's each time. I know some people on here have been ok w/o taking flagyl/vanco after C Diff, and some have not. I know I'll have to be half dead before ever taking them again, but if I have to, I'll take the vanco again because I don't ever want a repeat of C Diff. I hope everything goes ok for you!