Anyone have info on the c diff vaccine?

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mach1320
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Anyone have info on the c diff vaccine?

Postby mach1320 » Fri May 04, 2018 5:01 pm

I saw the initial vaccine failed but it looks like pfizer is currently holding clinical trials. I wouldn’t mind working in health care but the risk of infection just terrifies me. An effective vaccine sure would be amazing.

roy
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Re: Anyone have info on the c diff vaccine?

Postby roy » Fri May 04, 2018 5:06 pm

at a guess it's at least 10 years away.

mach1320
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Re: Anyone have info on the c diff vaccine?

Postby mach1320 » Fri May 04, 2018 7:14 pm

roy wrote:
> at a guess it's at least 10 years away.


I was hoping this could be a thing in 4-5, how great would it be. Guess it’s nice they’re acknowledging the need.

Preed
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Re: Anyone have info on the c diff vaccine?

Postby Preed » Sun May 06, 2018 10:15 am

I saw an article recently that a vaccine will be available as soon as 2020 from Pfizer

AllisS
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Re: Anyone have info on the c diff vaccine?

Postby AllisS » Sun May 06, 2018 10:29 am

I think the vaccine that's under development will only protect people from an initial C. diff infection, not from recurrence. If there's information to the contrary, please weigh in.
If your illness was preceded by use of a medication, e.g., an antibiotic, please fill out an FDA Adverse Event Report at http://www.fda.gov/Safety/MedWatch/default.htm

Preed
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Re: Anyone have info on the c diff vaccine?

Postby Preed » Sun May 06, 2018 10:44 am

Last year a "B" toxin neutralizing antibody vaccine was approved to prevent recurrence of c diff for high risk patients per Merck which will be a $250 million product

roy
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Re: Anyone have info on the c diff vaccine?

Postby roy » Sun May 06, 2018 11:07 am

Merck product was bezlotoxumab, AKA Zinplava
It's not a vaccine.

Preed
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Re: Anyone have info on the c diff vaccine?

Postby Preed » Sun May 06, 2018 11:10 am

Says it is on fiercebiotech.com

roy
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Re: Anyone have info on the c diff vaccine?

Postby roy » Sun May 06, 2018 11:33 am

Allis is correct.
A vaccine, if it's ever brought to the market will only be usefull if you never had c.diff.
it will not prevent infection but it will teach our immune system not to react to the toxin.
Asymptomatic carriage is the best the vaccine will offer.
If you have already had c.diff you probably already have the antibodies that the vaccine will produce.
Posters often pray for a vaccine but it's only usefully for preventing c.diff in future generations, (think clostridium tettani) it will not cure anyone who has an active infection.


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