Pulse Dosing

Treatments, possible treatments, unsubstantiated/unproven treatments. Consult your doctor first.
Guest

Postby Guest » Sat May 24, 2003 10:12 pm

Hi Natalia, <BR>You can also talk to one of the authors, Christina Surawicz, her contact info is below, and ask her for a reprint or pdf or whatever. Here's the abstract from sciencedirect: <BR> <BR>Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease <BR> <BR>Lynne V. McFarland Ph.D.a, c, Gary W. Elmer Ph.D.a and Christina M. Surawicz M.D., F.A.C.G.b, <BR> <BR>a Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, USA <BR>b Division of Gastroenterology, Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, USA <BR>c Biocodex, Inc., Seattle, Washington, USA <BR> <BR>Received 24 September 2001; accepted 29 January 2002. Available online 2 July 2002. <BR> <BR> <BR>Abstract <BR>OBJECTIVE: <BR> <BR>There is currently uncertainty as to the best treatment for patients with recurrent episodes of Clostridium difficile disease (RCDD). Our objective was to evaluate the success of treatment strategies in a cohort of 163 RCDD patients. <BR> <BR>METHODS: <BR> <BR>Data were used from patients who had participated in the placebo arm in two national referral clinical trials evaluating a new combination treatment. Patients with active RCCD were enrolled, prescribed either vancomycin or metronidazole, and randomized to either the investigational biological or a placebo. All patients were observed for at least 2 months for a subsequent episode of RCCD. <BR> <BR>RESULTS: <BR> <BR>Of the 163 cases, 44.8% recurred. A tapering course of vancomycin resulted in significantly fewer recurrences (31%, p = 0.01), as did pulsed dosing of vancomycin (14.3%, p = 0.02). A trend (p = 0.09) for a lower recurrence frequency was observed for high-dose (2 g/day) vancomycin and low-dose (1 g/day) metronidazole. Vancomycin was significantly more effective in clearing C. difficile culture and/or toxin by the end of therapy than metronidazole (89% vs 59%, respectively; p < 0.001). <BR> <BR>CONCLUSIONS: <BR> <BR>These data show that tapered or pulsed dosing regimens of vancomycin may result in a significantly better cure of RCDD. The persistence of C. difficile spores suggests that additional strategies to restore the normal colonic microflora may also be beneficial. <BR> <BR> <BR> Reprint requests and correspondence: Christina M. Surawicz, M.D., Division of Gastroenterology, Harborview Medical Center, 325 Ninth Avenue, Box 359773, , Seattle, WA 98104-2499 , USA

Guest

Postby Guest » Sat May 24, 2003 10:16 pm

oops, this is much more to the point. I found several copies that you have to pay for, but this one looks like the one you just register for and download the pdf. <BR> <BR>you can search for the article at: <BR> <!-- BBCode auto-link start --><a href="http://www.medicinedirect.com/journal/journal?sdid=6076" target="_blank">http://www.medicinedirect.com/journal/journal?sdid=6076</a><!-- BBCode auto-link end -->

Guest

Postby Guest » Mon May 10, 2004 2:25 am

Hi anyone; <BR> <BR>What is Laured's pulsing dosing? <BR> <BR>Wendy

Guest

Postby Guest » Wed Jul 07, 2004 12:25 pm

Cindym, <BR>I happen to see a post from you from Jan, 04. <BR>You were taking 250 vanco every 3rd day. Is that the regimen you are currently on? I have tapered down to 2 125 every day and probably will go 2 every other day next. In your opinion, does one dose carry more punch or dividing it into 2 dosages? Will not know until I try it but thought maybe you or someone else may have tried it both ways.. Do you remember how many weeks you stayed at each pulse?


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