Can you be Toxin A positive and Toxin B negative

[kanak]

I continue to have all the symptoms of c diff. I have had a few pcr tests since my FMT, all come back negative. I know it only tests for Toxin B. Could I have toxin A c diff if I have tested positive and been treated 3 times prior by a pcr being positive for B? Is this why it keeps coming back? My very first test was antigen positive toxin negative followed by a positive pcr next day.

How do I test for toxin A? My doctor only orders pcr testing and my Mayo doctor only orders pcr testing.
Thank you.

Amy

[amyc]

I'd try Alinia.

https://www.scripps.edu/newsandviews/e_ ... janda.html

The answer to your question is yes, some strains of C diff only make toxin A. Those strains are generally considered less serious, which is why the pcr test only looks for toxin B genes. I would be really surprised if you had toxin B forming C diff, got cured of that, and then developed a new infection with a different strain that only makes toxin A.

I recommend Alinia somewhat tongue in cheek, because it is a de-wormer. If a dog develops refractory D, most vets will prescribe de-wormer because it usually solves the problem. It would also work against Giardia, or at least it does in dogs. Best of luck on getting answers.

[georgina]

You can defintely be positive for toxin A only. I am still testing positive for Cdiff , just toxin A but the infection never went full blown so i decided to stop treating and i am still ok , with good and bad days.
There is no test that will determine just toxin A so you will have to get tested trough the EIA method , and to rule out false negatives you can request to be tested three days in a row.